Carboplatin dosing obesity
Webobese patients, with a normal renal function, a flat carboplatin dose should be administered, based on the population carboplatin clearance (8.38 l/h = 140 mL/min). Thus, in case an AUC of 5 mg min/mL is desired, the appropriate dose for carboplatin would be 5 9 140 = 700 mg. Keywords Carboplatin Dose adaptation Body weight Pharmacokinetics WebApr 2, 2012 · The maximum carboplatin dose should not exceed AUC (mg × min/mL) × 150 mL/min. Because carboplatin clearance is dictated by renal filtration, and GFR correlates with BSA, dosing of carboplatin in the obese patient with cancer based on …
Carboplatin dosing obesity
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WebFeb 17, 2024 · American Society for Blood and Marrow Transplantation (ASBMT) practice guideline committee position statement on chemotherapy dosing in obesity: Utilize actual body weight (full weight) for calculation of body surface area (when applicable) in carboplatin dosing for hematopoietic stem cell transplant conditioning regimens in … Webdosing using body weight or body surface area (BSA) [3] may be adjusted in obese patients due to concern for treatment-related toxicities [3, 4], despite The American Society of Clinical Oncology
WebAug 25, 2005 · When determining the carboplatin dosage from the Calvert formula, there are a lack of data when evaluating patients with cachexia or body mass index (BMI)≥27. If the Cockcroft and Gault (C-G) creatinine clearance (CrCl) equation is utilized and substituted for glomerular filtration rate in the Calvert formula, the chance for inaccurate … WebDose capping has been used to limit excess toxicity in obese patients at the risk of providing a less-effective regimen. Data suggest an increased dose of carboplatin, cisplatin, ifosfamide, paclitaxel, and vincristine may be needed in obese patients. The literature also suggests that no dosing alteration may be necessary for obese patients ...
WebOnly carboplatin dosing uses a target exposure (area under the curve [AUC]–based dosing) and maximum tolerated exposure; this exposure is rarely documented but rather aimed for through a series of formulas, estimations, and assumptions. ... Appropriate chemotherapy dosing for obese adult patients with cancer: American Society of Clinical ... WebUnreliable results may be obtained in patients who are outside the normal weight range (e.g. obese or cachectic patients). 4) The package insert does not provide a specific formula …
WebAug 7, 2024 · Cohorts included obese/overweight patients and normal-weight patients. Efficiency was measured by overall survival, progression-free survival and response rate. … magnum passionfruitWebAug 25, 2005 · In the C-G equation to determine creatinine clearance, the adjusted body weight was used for BMI>or=27 patients and serum creatinine value of 70.7 microM (0.8 mg/dl) for the cachectic patients. The carboplatin dose was calculated, administered to the patients, and subsequent carboplatin blood samples were obtained for pharmacokinetic … magnum partnersWebNov 7, 2008 · Carboplatin is a widely used platinum compound in combination chemotherapy regimens for the treatment of a number of malignancies. Carboplatin is mainly eliminated by the kidneys, as indicated by the fact that about 65% of the administered dose is excreted into the urine within the first 24 h after administration [].A small fraction … magnum passionWebApr 4, 2024 · Common carboplatin side effects may include: low blood cell counts; loss of appetite; nausea, vomiting, diarrhea; numbness, burning pain, or tingly feeling; temporary hair loss; or. pain in your hands or feet. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. magnumpg.comWebJul 2, 2015 · Key clinical point: Reduced chemotherapy doses based on BMI may compromise survival. Major finding: Average relative dose intensity lower than 70% was associated with both worse overall survival and worse ovarian cancer–specific survival. Data source: Cohort study of 806 women with epithelial magnum peak t5 accessoriesWebJul 30, 2024 · Dosing of carboplatin is complicated due to its relationship to renal function and narrow therapeutic index. Overestimation of renal function may lead to … craftstudio api 1.12.2WebUnreliable results may be obtained in patients who are outside the normal weight range (e.g. obese or cachectic patients). 4) The package insert does not provide a specific formula for GFR estimation. 5) AUC-based carboplatin dosing is more accurate than dosing according to BSA. magnumpfanne