Ctgf and liver fibrosis

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August undefined, 2024

WebApr 11, 2024 · various inﬂammatory modulators, including TGF-β and CTGF, in a paracrine manner has been reported. In addition to ... Liver fibrosis is a common pathological process of chronic liver diseases ... WebJun 13, 2024 · Connective tissue growth factor (CTGF, also known as CCN2), a member of the CCN family of matricellular proteins, is widely known as a hallmark of fibrosis in multiple tissues, including skin, heart, lung, liver, and kidney [ 3, 4 ].

Hepatic connective tissue growth factor expression and regulation ...

WebApr 11, 2024 · During chronic hepatitis B virus (HBV) infection, hepatic fibrosis is a serious pathological condition caused by virus-induced liver damage. The activation of hepatic stellate cells (HSCs) is a central event in the occurrence and progression of liver fibrosis. Although accumulating evidence has shown that HBV directly stimulates HSC activation, … WebAug 1, 2024 · The secretory character of CTGF and its production by various cell types in liver disease makes it a potential biomarker for the diagnosis of liver fibrosis and its progression. Several clinical studies have demonstrated significantly increased serum or plasma CTGF in patients with fibrotic/cirrhotic liver disease. share folder windows 10 to xp

Role of CTGF gene promoter methylation in the development of …

WebNov 1, 2024 · Paracrine factors such as platelet-derived growth factor (PDGF), transforming growth factor β (TGFβ), and connective tissue growth factor (CTGF), together with other growth factors and cytokines/chemokines, activate cellular signaling pathways of cell proliferation, migration, ECM protein secretion, and contractility that promote … WebHepatic fibrosis, which has characteristics of excessive deposition of extra cellular matrix (ECM), occurs by various chronic liver injuries, such as from chemicals, viral infection, … WebMay 8, 2024 · Connective tissue growth factor (CTGF) associated with transforming growth factor-β (TGF-β) play a pivotal role in the pathophysiology of many fibrotic disorders. … share folders windows 10

Hepatic stellate cells as key target in liver fibrosis - PMC

Liver Fibrosis: Therapeutic Targets and Advances in Drug Therapy

WebJan 21, 2024 · CTGF is a kind of matrix protein that is commonly up-regulated in the liver fibrosis, which plays a key role in liver fibrosis (Weiskirchen, 2016; Wu et al., 2024b; Makino et al., 2024). Studies have shown that hepatocytes, bile duct cells, HSCs and many other cells express and secrete CTGF protein in the fibrotic liver ( Williams et al., 2014 ... WebMar 20, 2024 · Liver fibrosis (LF) is caused by chronic liver injury from various causes, such as viral infections, alcohol consumption, non-alcoholic fatty liver disease (NAFLD), … poops wallpaperWebMar 20, 2024 · Liver fibrosis (LF) is caused by chronic liver injury from various causes, such as viral infections, alcohol consumption, non-alcoholic fatty liver disease (NAFLD), cholestatic liver disease, and autoimmune hepatitis. ... resulting in the inhibition of CTGF and its downstream targets . poop swatches south park

"WebMay 2, 2006 · Connective tissue growth factor (CTGF) is a highly profibrogenic molecule implicated in hepatic fibrogenesis. Small interfering RNA (siRNA) is an effective tool to … " - Ctgf and liver fibrosis

Ctgf and liver fibrosis

IJMS Free Full-Text Epoxyeicosatrienoic Acids and Fibrosis: …

WebApr 8, 2024 · Multiple studies illustrate the abilities of neutralizing anti-TGF-β antibodies and TGF-β receptor kinase inhibitors to prevent fibrosis in preclinical models of lung, liver, … WebJan 12, 2011 · In patients with IPF, CTGF levels are elevated in transbronchial biopsy specimens and in bronchoalveolar lavage fluid. Increased levels of CTGF have also been observed in experimental models of lung fibrosis. In addition, CTGF can cause susceptibility to experimentally-induced lung fibrosis in otherwise resistant mice.

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WebConnective tissue growth factor (CTGF) plays a critical role in the hepatic stellate cells (HSCs)-mediated development of hepatic fibrosis. Nevertheless, the effects of CTGF gene promoter methylation WebJun 5, 2024 · Therefore, NNMT, in conjunction with a NAM-rich diet, aggravates liver fibrosis, at least in part, through epigenetic changes to CTGF. Body weight and adiposity decreased in Tg mice fed an HFD ...

WebSep 1, 2006 · Results: The mean concentration of CTGF was highest in the fibrosis group (5.2-fold) and in the chronic viral hepatitis group (4.3-fold) but lower in those patients with fully developed cirrhosis. The area under the ROC curve (AUC) of CTGF for fibrosis vs control was 0.955 (95% confidence interval, 0.890–0.987). WebIn fibrotic liver, CTGF/CCN2 mRNA and protein are produced by fibroblasts, myofibroblasts, hepatic stellate cells (HSCs), endothelial cells, and bile duct …

WebDec 3, 2024 · Liver fibrosis is a multicellular response to liver injury in which hepatic stellate cells (HSCs) are responsible for 90% of extracellular matrix (ECM) production … WebJan 8, 2024 · Carbon tetrachloride (CCl4) is widely used to induce hepatic fibrosis. Therapeutic agents alleviate hepatic fibrosis by inhibiting signal transducer and activator …

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WebFeb 7, 2012 · Liver fibrosis is a major cause of liver failure, but treatment remains ineffective. In the present study, we investigated the mechanisms and anti-hepatofibrotic activities of asiatic acid (AA) in a rat model of liver fibrosis induced by carbon tetrachloride (CCl4) and in vitro in TGF-beta1-stimulated rat hepatic stellate cell line (HSC-T6). … share folder windows 10 ไม่ได้WebDec 3, 2024 · Liver fibrosis is a multicellular response to liver injury in which hepatic stellate cells (HSCs) are responsible for 90% of extracellular matrix (ECM) production [1,2,3,4,5].Liver fibrosis upon acute liver injury may be beneficial by providing mechanical stability and facilitating the restoration of hepatic architecture and function. share folder windows 10 ไม่ให้ถาม passwordWebConnective Tissue Growth Factor/CCN2. CTGF is a cysteine-rich 40 kDa matricellular growth factor implicated in angiogenesis, wound healing, and development. Although it is … poopsy commercial songWebMar 20, 2024 · Fibrosis, MMP-9, and TIMP-1 expressions in hEnSCs. (a) Cell viability of hEnSCs as determined in response to varying concentrations of CDDP. (b) Expressions of Collagen I, Collagen III, CTGF, Fibronectin, α-SMA, MMP-9, and TIMP-1 in hEnSCs within each group. A representative blot from one of the three independent experiments … poop sweatshirtWebHepatic fibrosis, which has characteristics of excessive deposition of extra cellular matrix (ECM), occurs by various chronic liver injuries, such as from chemicals, viral infection, and alcoholic or nonalcoholic hepatic steatosis [].Although the pathogenesis of hepatic fibrosis is not revealed clearly, hepatic stellate cells (HSCs) are believed to be a major role in the … share folder windows 10 to iphoneWebNov 1, 2024 · Paracrine factors such as platelet-derived growth factor (PDGF), transforming growth factor β (TGFβ), and connective tissue growth factor (CTGF), together with other … share folder windows 10 homeWebLong-term injury to liver cells and consistent activation of the fibrogenic response can lead to liver fibrosis such as that seen in chronic alcoholics or clinically obese individuals. … poopsy corn