Dichloromethylene diphosphonate
WebAbstract Systemic treatment with disodium ethane-hydroxy-1, 1-diphosphonate is ineffective in inhibiting the calcergenic reactions induced in mouse skin by the lanthanides. In contrast, disodium di... WebDaily administration of dichloromethylene diphosphonate (Cl2MDP) to (C57BL/6 X DBA/2) F1 hybrid mice, from two days of age (10 mg of P/kg body weight), resulted in a …
Dichloromethylene diphosphonate
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Web匡德宣， 王文广， 孙晓梅， 代解杰(中国医学科学院/北京协和医学院医学生物学研究所树鼩种质资源中心，云南省重大传染 ... WebIn mice administered with liposome-entrapped dichloromethylene diphosphonate, which depletes Kupffer cells, the size and the number of zymosan-induced granulomas in the liver were smaller than in untreated mice. The number of macrophage precursors, as detected by the monoclonal antibodies for macrophage precursors, increased after zymosan ...
WebDichloromethylene diphosphonate can be used for temporary elimination of macrophages in the spleen when administered after entrapment in liposomes. No comp Elimination of … WebDichloromethylene diphosphonate (MDPCl2) encapsulated in multilamellar liposomes was selectively incorporated by macrophages, immediately transferred to lysosomes, …
WebDepletion of AM by liposome-encapsulated dichloromethylene diphosphonate is shown to cause severalfold enhancement in systemic absorption of IgG and human chorionic gonadotropin after intratracheal instillation in rats. Lowering the doses of IgG delivered to the lungs alleviates local degradation and results in a dramatic increase in systemic ... WebMacrophages lining the subcapsular sinus (SCS) and those located in the medulla of popliteal lymph nodes (PLN) of mice were eliminated after subcutaneous (s.c.) injection of dichloromethylene diphosphonate (Cl2MDP)-containing liposomes. No effect of liposome-entrapped Cl2MDP could be seen on nonphag …
WebThe daily subcutaneous administration of (dichloromethylene)diphosphonate (clodronate) to 3-day-old normal inbred Wistar-Furth rats for 30 days produces osteopetrotic bone …
WebIt is shown ultrastructurally that intravenously injected and liposome-entrapped dichloromethylene diphosphonate (DMDP) causes marked damage to marginal zone macrophages in the mouse spleen which finally results in the elimination of these cells. slow cooking salmon in ovenWebDMDP is ingested by phagocytic cells when entrapped in liposomes. Once phagocytized the liposomal membranes are digested and the drug is released into the cell and is ready for action. In vitro, even low doses of liposome-entrapped DMDP caused an significant reduction in cell numbers. software 2018 roWebMar 15, 2000 · Liposomes containing dichloromethylene diphosphonate (L-DMDP) were injected 45 hours prior to the injection of OxRBC. (A) Liver uptake (circles) and blood decay (triangles) of OxRBC after pretreatment with L-DMDP (closed symbols) or after injection of phosphate-buffered saline (PBS) (open symbols) as control. ... software 2016WebSep 1, 1996 · Abstract. Dichloromethylene diphosphonate (MDPCl 2) encapsulated in multilamellar liposomes was selectively incorporated by macrophages, immediately … slow cooking round steakWebPhosphonic acid, (dichloromethylene)bis-, disodium salt CH2Cl2Na2O6P2 CID 73554303 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … slow cooking short ribsWebIt is shown ultrastructurally that intravenously injected and liposome-entrapped dichloromethylene diphosphonate (DMDP) causes marked damage to marginal zone … software 2017WebIt is shown ultrastructurally that intravenously injected and liposome-entrapped dichloromethylene diphosphonate (DMDP) causes marked damage to marginal zone … software 2020