Myotubularin-related protein 3
WebBackground Kidney injury in the course of chronic kidney disease (CKD) is a consequence of aggravated cell migration, inflammation, apoptosis, and fibrosis. However, the sequence of these phenomena, as well as of the reparatory mechanisms, are not fully known. Monocyte chemoattractant protein 1 (MCP-1) and macrophage colony-stimulating factor (MCSF) … WebMay 1, 2012 · The myotubularin family consists of 16 different proteins, 9 members of which possess catalytic activity (10, 11) and 7 members that are inactive.Myotubularin proteins are not redundant and have unique functions within cells by regulating a specific pool of dephosphorylating phosphatidylinositol 3-phosphate [PtdIns(3)P] and …
Myotubularin-related protein 3
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WebRegulation of phosphatidylinositol phosphates plays a crucial role in signal transduction, membrane trafficking or autophagy.Members of the myotubularin family of lipid phosphatases contribute to phosphoinositide metabolism by counteracting the activity of phosphoinositide kinases. The mechanisms determining their subcellular localization and … WebDescription: myotubularin related protein 10 Transcript (Including UTRs) Position: hg18 chr15:29,018,436-29,029,831 Size: 11,396 Total Exon Count: 4 Strand: - Coding ...
http://www.informatics.jax.org/marker/MGI:1921552 WebNov 8, 2024 · Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MTMR3 (myotubularin related protein 3). [provided by Alliance of Genome Resources, Apr 2024] Other …
WebApr 12, 2024 · Down-regulated miR-99a was able to inhibit the spreading of oral cancer cells by decreasing the expression of Myotubularin-related protein 3 (MTMR3). It has been suggested that MTMR3 could be used as a therapeutic intervention in the management of oral cancer . Expression of miR-99a-5p in OSCC tissues and cell lines (CAL-27 and TCA … WebMyotubularin-related proteins constitute one of the largest and most highly conserved protein tyrosine phosphatase (PTP) subfamilies in eukaryotes [14, 19]. The MTM family …
WebApr 5, 2002 · Sequence comparisons of the conserved protein-tyrosine phosphatase/dual-specificity phosphatase regions of myotubularin family members indicated that MTMR3 represents a distinct subgroup. Northern blot analysis revealed that the MTMR3 gene is expressed ubiquitously as several transcripts.
WebAs a member of the myotubularin family, myotubularin related protein 3 (MTMR3) has been demonstrated to participate in tumor development, including oral and colon cancer. … loan to rehab a houseWebFeb 8, 2002 · Myotubularin is the archetype of a family of highly conserved protein-tyrosine phosphatase-like enzymes. The myotubularin gene, MTM1, is mutated in the genetic disorder, X-linked myotubular myopathy.We and others have previously shown that myotubularin utilizes the lipid second messenger, phosphatidylinositol 3-phosphate … loan to repair houseWebMTMR3, myotubularin related protein 3 Vertebrate Orthologs 3 Vertebrate Orthology Source. Alliance of Genome Resources. Human Ortholog MTMR3, myotubularin related protein 3. Synonyms FYVE-DSP1, ZFYVE10 Links HGNC:7451. NCBI Gene ID: 8897. neXtProt AC: NX_Q13615. UniProt ... indiana product liability lawyerWebthe wild-type enzyme, demonstrating that PI(3)P is a substrate for myotubularininvivo.Inaddition,aSaccharomycescerevisiaestrain in which the myotubularin-like gene (YJR110w) is disrupted also exhibits increased PI(3)P levels. Both the recombinant yeast en-zyme and a human myotubularin-related protein (KIAA0371) are loan to trust from individualWebJul 18, 2000 · Myotubularin phosphatase activity is highly specific toward PI(3)P, and MTM1mutations that cause myotubular myopathy render the enzyme catalytically … indiana producers licenseWebMTMR2 myotubularin related protein 2 Gene ID: 8898, updated on 29-Mar-2024 Gene type: protein coding ... The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive ... loan to stop foreclosureMyotubularin domain represents a region within eukaryotic myotubularin-related proteins that is sometimes found with the GRAM domain InterPro: IPR004182. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate. Mutations in gene encoding myotubularin-related proteins have been associat… indiana producer life insurance license