WitrynaAmerican Physiological Society Journal Home Witryna22 paź 2024 · Organic anion transporter 2 (OAT2 or SLC22A7 ) plays an important role in the hepatic uptake and renal secretion of several endogenous compounds and …
Identification of Organic Anion Transporter 2 Inhibitors: …
WitrynaThe organic anion transporter protein (OATP) SLC21 family contains 11 verified human genes. ... demonstrating an intracellular orientation of the C-terminal end. On the basis of these experiments, an 8-TMD topology was excluded but the calculated 7- and 9-TMD models were not further verified (Geyer et al., 2007). Members of the Organo Anion Transporter (OAT) Family (organic-anion-transporting polypeptides, OATP) are membrane transport proteins or 'transporters' that mediate the transport of mainly organic anions across the cell membrane. Therefore, OATPs are present in the lipid bilayer of the cell membrane, acting as … Zobacz więcej Proteins of the OAT family catalyze the Na -independent facilitated transport of fairly large amphipathic organic anions (and less frequently neutral or cationic drugs), such as bromosulfobromophthalein, prostaglandins, … Zobacz więcej The OATPs play a role in the transport of some classes of drugs across the cell membrane, particularly in the liver and kidney. In the liver, OATPs are expressed on the … Zobacz więcej The various paralogues in a mammal have differing but overlapping substrate specificities and tissue distributions as summarized by Hagenbuch and Meier. These authors … Zobacz więcej The table below shows the 11 known human OATPs. Note: Human OATPs are designated with capital letters, animal Oatps are designated with lower class letters. The … Zobacz więcej OATPs are present in many animals, including fruit flies, zebrafish, dogs, cows, rats, mice, monkeys and horses. OATPs are not present … Zobacz więcej check at\u0026t voicemail from another phone
Organic Anion Transporter - an overview ScienceDirect Topics
WitrynaWe have cloned a cDNA coding for a novel member of organic anion transporter, designated OAT-K1, expressed specifically in the kidney of rats. The rat OAT-K1 … WitrynaThe organic anion transporters ( OAT s), part of the SLC22 superfamily of transporters, are expressed throughout the body. However, the most clinically relevant members of this sub-family of transporters, OAT1 ( gene: SLC22A6) and OAT3 (gene: SLC22A8 ), are mainly localized to the basolateral membrane of the renal proximal … The organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cel… check att internet connection